abstract：:The potential clinical efficacy of tiagabine for control of status epilepticus was evaluated in an experimental model. Tiagabine was administered to cobalt-lesioned rats in which status epilepticus was induced by injection of homocysteine thiolactone. Tiagabine was effective in controlling status epilepticus in this m...

journal_title：Epilepsy research

authors： Walton NY,Gunawan S,Treiman DM

更新日期：1994-12-01 00:00:00

abstract：:Dichotic word listening asymmetries are thought to be useful in predicting side of temporal lobe dysfunction. However, little direct evidence exists to support this assumption in practice, especially in patients with subtle epileptogenic lesions. To determine if word listening ear asymmetries are valid predictors of s...

journal_title：Epilepsy research

authors： Lee GP,Loring DW,Varney NR,Roberts RJ,Newell JR,Martin JA,Smith JR,King DW,Meador KJ,Murro AM

更新日期：1994-10-01 00:00:00

abstract：:Much remains to be learned about mechanisms underlying entry into, and temporal progression of, status epilepticus (SE). This report describes a non-pharmacologic model of generalized convulsive SE in rat. Pulsed trains of suprathreshold electric current, were administered bilaterally to either of four rostral forebra...

journal_title：Epilepsy research

authors： Handforth A,Treiman DM

更新日期：1994-09-01 00:00:00

abstract：:Previous investigations in seizure-prone mice have suggested that an abnormally elevated production of the astrocyte-derived neuroexcitant, quinolinic acid (QUIN), plays a role in seizure susceptibility. In order to evaluate further the role of QUIN metabolism in genetic murine seizure models, the activities of its bi...

journal_title：Epilepsy research

authors： Eastman CL,Urbańska EM,Chapman AG,Schwarcz R

更新日期：1994-07-01 00:00:00

abstract：:An earlier pharmacodynamic study of the chiral antiepileptic drug stiripentol in an intravenous pentylenetetrazol-induced seizure model in the rat showed the development of a significant degree of tolerance to the anticonvulsant and neurotoxic effects following subacute treatment with the racemic compound. A more rece...

journal_title：Epilepsy research

authors： Arends RH,Zhang K,Levy RH,Baillie TA,Shen DD

更新日期：1994-06-01 00:00:00

abstract：:The role of N-methyl-D-aspartate (NMDA) in the development and expression of kindled seizures was assessed using a crossover design. Rats were stimulated once daily in the perforant path for 10 consecutive days 30 min following daily administration of saline or the NMDA antagonist MK-801 (1.0 mg/kg) (phase I). Five to...

journal_title：Epilepsy research

authors： Gilbert ME

更新日期：1994-02-01 00:00:00

abstract：:The investigational anticonvulsant drug, gabapentin (GP; 1-(aminomethyl) cyclohexaneacetic acid) limited repetitive firing of sodium-dependent action potentials of mouse spinal cord and neocortical neurons in monolayer dissociated cell culture. The effect developed slowly over time with sustained exposure. The IC50 wa...

journal_title：Epilepsy research

authors： Wamil AW,McLean MJ

更新日期：1994-01-01 00:00:00

abstract：:We studied the electrocorticogram (ECoG) before and immediately after transcortical selective amygdalo-hippocampectomy, prospectively in 13 consecutive patients and retrospectively in three others. ECoG was performed with surface and two depth electrodes inserted through T2 aimed at the amygdala and anterior hippocamp...

journal_title：Epilepsy research

authors： Cendes F,Dubeau F,Olivier A,Cukiert A,Andermann E,Quesney LF,Andermann F

更新日期：1993-12-01 00:00:00

abstract：:The effects of GABA uptake inhibitors, SKF 89976A and SKF 100330A, on recurrent inhibition were studied in the rat hippocampal slice preparation by the antidromic-orthodromic stimulation test. Population spikes evoked orthodromically by stimulation of the stratum radiatum and recorded in the CA1 pyramidal cell body la...

journal_title：Epilepsy research

authors： Capek R,Esplin B

更新日期：1993-10-01 00:00:00

abstract：:Binding of valproate and palmitate to serum albumin was studied in 29 valproate-treated epileptic patients. The results were compared with similar observations in a reference group of 43 non valproate-treated individuals. The binding affinity for palmitate was decreased (P < 0.0001) resulting in increased availability...

journal_title：Epilepsy research

authors： Vorum H,Gram L,Honoré B

更新日期：1993-09-01 00:00:00

abstract：:The anticonvulsant activities of a noncompetitive (GYKI 52466) and a competitive (NBQX) AMPA/kainate antagonist were compared in the maximal electroshock (MES) seizure test and various chemoconvulsant models. Both antagonists were protective in the MES and pentylenetetrazol tests. GYKI 52466 was also protective agains...

journal_title：Epilepsy research

authors： Yamaguchi S,Donevan SD,Rogawski MA

更新日期：1993-07-01 00:00:00

abstract：:The intracarotid amobarbital procedure (IAP) was attempted in 22 pediatric epilepsy surgery candidates, ages 5-12 years old. With extra pre-test teaching and emotional preparation, adjusted amobarbital dosage for younger patients, and simplified test items tailored to the child's abilities, language and memory testing...

journal_title：Epilepsy research

authors： Szabó CA,Wyllie E

更新日期：1993-07-01 00:00:00

abstract：:The behavioral and EEG concomitants of kindling produced by daily electrical stimulation of the inferior colliculus have been recorded in three series of Wistar rats: (1) non epileptic controls (NE), (2) rats susceptible to audiogenic seizures (AS), (3) acoustically susceptible rats with prior kindling of audiogenic s...

journal_title：Epilepsy research

authors： Hirsch E,Maton B,Vergnes M,Depaulis A,Marescaux C

更新日期：1993-06-01 00:00:00

abstract：:The new antiepileptic drug zonisamide was evaluated in a European multicenter parallel-group double-blind trial as add-on treatment for 139 patients with refractory partial epilepsy. During treatment with zonisamide complex partial seizures decreased by 27.7% compared to placebo (P < 0.05) and the median rate dropped ...

journal_title：Epilepsy research

authors： Schmidt D,Jacob R,Loiseau P,Deisenhammer E,Klinger D,Despland A,Egli M,Bauer G,Stenzel E,Blankenhorn V

更新日期：1993-05-01 00:00:00

abstract：:Brain slices from adult rats that included ventral hippocampus and adjacent parahippocampal areas were studied at various sites for the appearance of epileptiform discharges as extracellular potassium ([K+]o) was systematically varied over the range of 3 mM to 10 mM. The development of evoked epileptiform discharges (...

journal_title：Epilepsy research

authors： Bear J,Lothman EW

更新日期：1993-03-01 00:00:00

abstract：:Generalized seizures can induce both hypertension and hyperglycemia which may aggravate preexisting cerebral or medical conditions in patients. In vivo fluorescent imaging of regional cortical blood flow and brain intracellular pH (pHi) was performed in fasted New Zealand rabbits (n = 35) in which either mean arterial...

journal_title：Epilepsy research

authors： Tomlinson FH,Anderson RE,Meyer FB

更新日期：1993-02-01 00:00:00

abstract：:The present study aimed at investigating to what extent the regulation of excitability in cortical networks, as indicated by surface-negative slow cortical potentials (SCPs), is impaired in epileptic patients and to what extent training of SCP self-regulation by means of biofeedback and instrumental learning procedure...

journal_title：Epilepsy research

authors： Rockstroh B,Elbert T,Birbaumer N,Wolf P,Düchting-Röth A,Reker M,Daum I,Lutzenberger W,Dichgans J

更新日期：1993-01-01 00:00:00

abstract：:The present study investigated whether pharmacological stimulation of the GABAergic system can affect attention. The effects of vigabatrin, a novel antiepileptic drug, on the performance of rats in a 5-choice serial reaction time task assessing selective attention were studied. The effects of acute (100, 300, 500 and ...

journal_title：Epilepsy research

authors： Mazurkiewicz M,Sirviö J,Riekkinen P Sr

更新日期：1992-12-01 00:00:00

abstract：:The motivational consequences of kindling were examined in the conditioned place preference paradigm. In a distinctive environment, rats received stimulation of the amygdala that triggered afterdischarge (AD) alone or AD and generalized seizures. After 4 conditioning trials, preference for the conditioning environment...

journal_title：Epilepsy research

authors： Corcoran ME,Lanius R,Duren A

更新日期：1992-12-01 00:00:00

abstract：:We compared the relative sensitivity of two interictal PET techniques, bolus injection of [15O] labeled water for estimation of cerebral blood flow (H2(15)O CBF-PET), and 18F 2-deoxyglucose (18FDG-PET) for cerebral glucose metabolism (CMRglc), and T2-weighted magnetic resonance imaging, in 28 patients with medically i...

journal_title：Epilepsy research

authors： Leiderman DB,Balish M,Sato S,Kufta C,Reeves P,Gaillard WD,Theodore WH

更新日期：1992-11-01 00:00:00

abstract：:Single photon emission computed tomography (SPECT) is increasingly being used as an adjunctive technique in the localisation of epileptogenic foci prior to surgery. As yet, few studies have been undertaken to establish the clinical associations of areas of reduced cerebral perfusion. Sixty-three consecutive patients (...

journal_title：Epilepsy research

authors： Duncan S,Gillen G,Adams FG,Duncan R,Brodie MJ

更新日期：1992-10-01 00:00:00

abstract：:Alterations in the level of consciousness may render the interpretation of the memory test results from the intracarotid amobarbital procedure difficult. The present study was designed to investigate the impact of inattention and somnolence on memory performance during the Amytal test. Nineteen consecutive patients un...

journal_title：Epilepsy research

authors： Malmgren K,Bilting M,Hagberg I,Hedström A,Silfvenius H,Starmark JE

更新日期：1992-09-01 00:00:00

abstract：:Polyamine (tissue) concentrations have been studied in hippocampus and temporal neocortex from patients with temporal lobe epilepsy. Depth electrode recordings demonstrated hippocampal origin of the seizures, the temporal neocortex being involved during the discharge propagation. Neuropathological examination of excis...

journal_title：Epilepsy research

authors： Laschet J,Trottier S,Grisar T,Leviel V

更新日期：1992-07-01 00:00:00

abstract：:The AMPA/KA receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and the NMDA receptor antagonist 2-amino-5-phosphonovalerate (D-APV) were used to investigate the contribution of excitatory amino acid (EAA) receptors to graded bursting activity recorded in the CA1 region of the rat hippocampal slice followi...

journal_title：Epilepsy research

authors： Williamson R,Wheal HV

更新日期：1992-07-01 00:00:00

abstract：:Clinical practitioners have often observed in the course of their daily work that the pain thresholds of epileptic patients seem to differ from those of healthy subjects. These patients can suffer from quite severe traumatic lesions without apparently experiencing any pain. Since they are usually under treatment for e...

journal_title：Epilepsy research

authors： Guieu R,Mesdjian E,Roger J,Dano P,Pouget J,Serratrice G

更新日期：1992-06-01 00:00:00

abstract：:Audiogenic seizures in genetically susceptible rodents are provoked by intense acoustic stimulations which result in a tonic seizure associated with a short flattening of the EEG. These seizures have been shown to involve primarily brainstem structures. Daily exposure to sound for 30-40 days produced a permanent chang...

journal_title：Epilepsy research

authors： Hirsch E,Maton B,Vergnes M,Depaulis A,Marescaux C

更新日期：1992-05-01 00:00:00

abstract：:We report an interaction between lamotrigine (LTG), a new antiepileptic drug (AED), and carbamazepine (CBZ) and its primary metabolite CBZ-10,11-epoxide (CBZ-E) in 9 consecutive patients (5 male, 4 female, aged 19-31 years). After introduction of LTG (median daily dose 200 mg, range 100-300 mg) the mean serum CBZ-E co...

journal_title：Epilepsy research

authors： Warner T,Patsalos PN,Prevett M,Elyas AA,Duncan JS

更新日期：1992-04-01 00:00:00

abstract：:Oxcarbazepine (OXC) is considered to be a promising new antiepileptic drug with similar efficacy and better tolerability compared to carbamazepine (CBZ). However, hyponatremia is supposed to occur even more often than with CBZ. We report on a patient who developed hyponatremic coma under OXC with a serum sodium level ...

journal_title：Epilepsy research

authors： Steinhoff BJ,Stoll KD,Stodieck SR,Paulus W

更新日期：1992-03-01 00:00:00

abstract：:Dapsone (4,4'-diaminodiphenyl sulfone; DDS), an established anti-leprosy drug, showed anticonvulsive effects in the amygdaloid kindling model of epilepsy. Single doses of the drug in rats (6.25-12.5 mg/kg, i.p.) suppressed the kindled seizures in a dose-dependent manner without overt behavioral toxicity. With repeated...

journal_title：Epilepsy research

authors： Hamada K,Hiyoshi T,Kobayashi S,Ishida S,Yagi K,Seino M

更新日期：1991-11-01 00:00:00

abstract：:The effect of magnesium-free medium on electrical and CaM kinase II activity in the rat hippocampal slice was examined. Experimental slices were incubated in 2 mM Mg, then exposed to magnesium-free medium for 1 h. Control slices were concurrently run in 2 mM Mg. Slices were then frozen and CaM kinase II activity was m...

journal_title：Epilepsy research

authors： Churn SB,Anderson WW,DeLorenzo RJ

更新日期：1991-09-01 00:00:00

abstract：:This paper reports the results of a 12-month prospective follow-up study on the effects of carbamazepine (CBZ) medication on serum sex and pituitary hormone concentrations in 21 male patients with recently diagnosed epilepsy. The results of the present study indicate that a change occurs in the androgen balance during...

journal_title：Epilepsy research

authors： Isojärvi JI,Pakarinen AJ,Myllylä VV

更新日期：1991-07-01 00:00:00

abstract：:The effect and safety of loreclezole were evaluated during a long-term follow-up trial targeting higher plasma concentrations than those of the preceding controlled trial. The result is better than in the double-blind trial, in which loreclezole doses were administered to reach plasma concentrations of 1-2 mg/l and 6/...

journal_title：Epilepsy research

authors： Rentmeester T,Janssen A,Hulsman J,Scholtes F,van der Kleij B,Overweg J,Meijer J,de Beukelaar F

更新日期：1991-05-01 00:00:00

abstract：:Hemimegalencephaly (HME) is a severe unilateral brain malformation the prognosis of which may be improved by hemispherectomy. HME also provides a unique opportunity to compare normal and pathological hemispheric function in the same patient. We performed a serial functional cerebral imaging study in a child suffering ...

journal_title：Epilepsy research

authors： Chiron C,Raynaud C,Jambaqué I,Dulac O,Zilbovicius M,Syrota A

更新日期：1991-04-01 00:00:00

abstract：:We examined the influence of seizures and carbamazepine (CBZ) on spiking rates in kindled cats. In the first experiment, spiking rates were measured before and after seizures, with and without CBZ. CBZ was administered immediately after seizures in order not to affect them. Spiking rates were measured over 9 h during ...

journal_title：Epilepsy research

authors： Gigli GL,Gotman J

更新日期：1991-04-01 00:00:00

abstract：:In rats, electrographic seizure activity was recorded from both the inferior collicular cortex and the deep prepiriform after i.p. administration of 15 mumol/kg bicuculline, a dose which produced a variety of seizure behaviors. electrographic spikes recorded from the deep prepiriform cortex coincided with myoclonic je...

journal_title：Epilepsy research

authors： McCown TJ,Breese GR

更新日期：1991-01-01 00:00:00

abstract：:A battery of psychometric tests was administered to 110 patients with epilepsy and to 24 non-epileptic controls. Eighty-four patients had been established on treatment with a single anticonvulsant drug (35 carbamazepine (CBZ), 30 sodium valproate (VPA), 19 phenytoin (PHT)) at unaltered dosage for the previous 3 months...

journal_title：Epilepsy research

authors： Gillham RA,Williams N,Wiedmann KD,Butler E,Larkin JG,Brodie MJ

更新日期：1990-12-01 00:00:00

abstract：:The effects of a novel anticonvulsant, zonisamide (3-sulfamoylmethyl-1,2-benzisoxazole), on photically induced seizures were studied in the lateral geniculate-kindled cat. Zonisamide was found to reduce the behavioral severity of seizure responses to photic stimulation in a dose-related manner. This anticonvulsant eff...

journal_title：Epilepsy research

authors： Wada Y,Hasegawa H,Yamaguchi N

更新日期：1990-11-01 00:00:00

abstract：:The distribution and kinetics of specific binding sites for gamma-hydroxybutyrate (GHB), a naturally occurring compound known to produce absence-like seizures, was studied in the brains of Wistar rats with spontaneous, bilaterally synchronous spike wave discharges (SWDs), a model of petit mal epilepsy, and non-epilept...

journal_title：Epilepsy research

authors： Snead OC 3rd,Hechler V,Vergnes M,Marescaux C,Maitre M

更新日期：1990-11-01 00:00:00

abstract：:The actions of adenosine in modulating amygdala kindling were examined using the stable adenosine analog 5'-N'-ethylcarboxamidoadenosine (NECA) and caffeine, an adenosine antagonist. Systemically administered NECA was found to significantly reduce the rate of postictal spiking and to significantly increase the duratio...

journal_title：Epilepsy research

authors： Whitcomb K,Lupica CR,Rosen JB,Berman RF

更新日期：1990-08-01 00:00:00

abstract：:Early neuropsychological changes following partial anterior callosotomy were evaluated in 15 patients with epilepsy (10 secondary generalized and 5 Lennox-Gastaut syndromes) by comparing their performances 1 month before surgery and then 15-20 and 90-100 days postoperatively without modifying the anticonvulsant treatm...

journal_title：Epilepsy research

authors： Provinciali L,Del Pesce M,Censori B,Quattrini A,Paggi A,Ortenzi A,Mancini S,Papo I,Rychlicki F

更新日期：1990-07-01 00:00:00